Effects of Fusarium Mycotoxin Exposure on Lipid Peroxidation and Glutathione Redox System in the Liver of Laying Hens

It has been proven by several studies that Fusarium mycotoxins induce oxidative stress in animals, consequently inducing lipid peroxidation, which the glutathione system can neutralize. A short-term (3-day) vivo feeding trial was performed with laying hens using a double dose of EU recommendation for mycotoxin contamination (T-2 toxin 0.5 mg/kg feed; deoxynivalenol (DON) 10 fumonisin B1 (FB1) 40 feed). Some peroxidation and redox parameters gene expression levels were measured liver. The results show FB1 significantly decreased reduced (GSH) content activity peroxidase (GPx) compared to control two other mycotoxin-treated groups on day 3. Lipid affected all three mycotoxins. Significantly lower values observed case conjugated dienes malondialdehyde concentration as an effect DON T-2 upregulated GPX4 gene. had different effects at end trial. exposure caused decrease markers, while formation malondialdehyde. suggest investigated individually differently activated antioxidant defense low-level applied.